{"symbol":"PAPPA2","synonyms":["PAPPE","PLAC3","PAPP-E","PAPP-A2"],"name":"pappalysin 2","description":"This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]","ncbiEntrezGeneId":60676,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/60676","proteins":[{"symbol":"PAPP2_HUMAN","href":"/api/1.0/protein/PAPP2_HUMAN"}],"hgncRootFamilies":[{"name":"Metzincin metallopeptidases","href":"/api/1.0/gene_family/Metzincin+metallopeptidases"}]}