{"symbol":"PARD6A","synonyms":["PAR-6A","TAX40","PAR6C","PAR6","TIP-40","PAR6ALPHA"],"name":"par-6 family cell polarity regulator alpha","description":"This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":50855,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/50855","proteins":[{"symbol":"PAR6A_HUMAN","href":"/api/1.0/protein/PAR6A_HUMAN"}],"hgncRootFamilies":[]}