{"symbol":"PARP4","synonyms":["PARP-4","VWA5C","ADPRTL1","PARPL","VAULT3","VPARP","P193","PH5P","ARTD4"],"name":"poly (ADP-ribose) polymerase family, member 4","description":"This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":143,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/143","proteins":[{"symbol":"PARP4_HUMAN","href":"/api/1.0/protein/PARP4_HUMAN"}],"hgncRootFamilies":[{"name":"Poly (ADP-ribose) polymerases (PARP)","href":"/api/1.0/gene_family/Poly+%28ADP-ribose%29+polymerases+%28PARP%29"}]}