{"symbol":"PAX8","synonyms":[],"name":"paired box 8","description":"This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]","ncbiEntrezGeneId":7849,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7849","proteins":[{"symbol":"PAX8_HUMAN","href":"/api/1.0/protein/PAX8_HUMAN"}],"hgncRootFamilies":[{"name":"Homeoboxes","href":"/api/1.0/gene_family/Homeoboxes"},{"name":"Paired boxes (PAX)","href":"/api/1.0/gene_family/Paired+boxes+%28PAX%29"}]}