{"symbol":"PCNT","synonyms":["KEN","MOPD2","PCNTB","PCNT2","SCKL4","PCTN2","PCN"],"name":"pericentrin","description":"The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]","ncbiEntrezGeneId":5116,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5116","proteins":[{"symbol":"PCNT_HUMAN","href":"/api/1.0/protein/PCNT_HUMAN"}],"hgncRootFamilies":[]}