{"symbol":"PDCD1","synonyms":["SLEB2","PD1","HSLE1","CD279","PD-1","HPD-1","HPD-L"],"name":"programmed cell death 1","description":"Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]","ncbiEntrezGeneId":5133,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5133","proteins":[{"symbol":"PDCD1_HUMAN","href":"/api/1.0/protein/PDCD1_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}