{"symbol":"PDE11A","synonyms":["PPNAD2"],"name":"phosphodiesterase 11A","description":"The 3\u0027,5\u0027-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3\u0027,5\u0027-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5\u0027-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":50940,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/50940","proteins":[{"symbol":"PDE11_HUMAN","href":"/api/1.0/protein/PDE11_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphodiesterases (PDE)","href":"/api/1.0/gene_family/Phosphodiesterases+%28PDE%29"}]}