{"symbol":"PDE1A","synonyms":["HCAM1","HSPDE1A","HCAM-1","CAM-PDE 1A","CAM-PDE-1A"],"name":"phosphodiesterase 1A, calmodulin-dependent","description":"Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]","ncbiEntrezGeneId":5136,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5136","proteins":[{"symbol":"PDE1A_HUMAN","href":"/api/1.0/protein/PDE1A_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphodiesterases (PDE)","href":"/api/1.0/gene_family/Phosphodiesterases+%28PDE%29"}]}