{"symbol":"PDE4A","synonyms":["DPDE2","PDE4","PDE46"],"name":"phosphodiesterase 4A, cAMP-specific","description":"The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]","ncbiEntrezGeneId":5141,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5141","proteins":[{"symbol":"PDE4A_HUMAN","href":"/api/1.0/protein/PDE4A_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphodiesterases (PDE)","href":"/api/1.0/gene_family/Phosphodiesterases+%28PDE%29"}]}