{"symbol":"PDGFA","synonyms":["PDGF1","PDGF-A"],"name":"platelet-derived growth factor alpha polypeptide","description":"This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]","ncbiEntrezGeneId":5154,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5154","proteins":[{"symbol":"PDGFA_HUMAN","href":"/api/1.0/protein/PDGFA_HUMAN"}],"hgncRootFamilies":[]}