{"symbol":"PDGFRA","synonyms":["PDGFR-2","CD140A","PDGFR2","RHEPDGFRA"],"name":"platelet-derived growth factor receptor, alpha polypeptide","description":"This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":5156,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5156","proteins":[{"symbol":"PGFRA_HUMAN","href":"/api/1.0/protein/PGFRA_HUMAN"}],"hgncRootFamilies":[{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}