{"symbol":"PDIA2","synonyms":["PDA2","PDIP"],"name":"protein disulfide isomerase family A, member 2","description":"This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]","ncbiEntrezGeneId":64714,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64714","proteins":[{"symbol":"PDIA2_HUMAN","href":"/api/1.0/protein/PDIA2_HUMAN"}],"hgncRootFamilies":[{"name":"Protein disulfide isomerases (PDI)","href":"/api/1.0/gene_family/Protein+disulfide+isomerases+%28PDI%29"}]}