{"symbol":"PDIA5","synonyms":["PDIR"],"name":"protein disulfide isomerase family A, member 5","description":"This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]","ncbiEntrezGeneId":10954,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10954","proteins":[{"symbol":"PDIA5_HUMAN","href":"/api/1.0/protein/PDIA5_HUMAN"}],"hgncRootFamilies":[{"name":"Protein disulfide isomerases (PDI)","href":"/api/1.0/gene_family/Protein+disulfide+isomerases+%28PDI%29"}]}