{"symbol":"PDIA6","synonyms":["TXNDC7","ERP5"],"name":"protein disulfide isomerase family A, member 6","description":"This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]","ncbiEntrezGeneId":10130,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10130","proteins":[{"symbol":"PDIA6_HUMAN","href":"/api/1.0/protein/PDIA6_HUMAN"}],"hgncRootFamilies":[{"name":"Protein disulfide isomerases (PDI)","href":"/api/1.0/gene_family/Protein+disulfide+isomerases+%28PDI%29"}]}