{"symbol":"PENK","synonyms":["PE","PENK-A"],"name":"proenkephalin","description":"This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]","ncbiEntrezGeneId":5179,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5179","proteins":[{"symbol":"PENK_HUMAN","href":"/api/1.0/protein/PENK_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}