{"symbol":"PFKFB1","synonyms":["F6PK","HL2K","PFRX"],"name":"6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1","description":"This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]","ncbiEntrezGeneId":5207,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5207","proteins":[{"symbol":"F261_HUMAN","href":"/api/1.0/protein/F261_HUMAN"}],"hgncRootFamilies":[]}