{"symbol":"PFN1","synonyms":["ALS18"],"name":"profilin 1","description":"This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]","ncbiEntrezGeneId":5216,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5216","proteins":[{"symbol":"PROF1_HUMAN","href":"/api/1.0/protein/PROF1_HUMAN"}],"hgncRootFamilies":[]}