{"symbol":"PHF1","synonyms":["TDRD19C","HPHF1","PHF2","MTF2L2"],"name":"PHD finger protein 1","description":"This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]","ncbiEntrezGeneId":5252,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5252","proteins":[{"symbol":"PHF1_HUMAN","href":"/api/1.0/protein/PHF1_HUMAN"}],"hgncRootFamilies":[{"name":"Tudor domain containing (TDRD)","href":"/api/1.0/gene_family/Tudor+domain+containing+%28TDRD%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}