{"symbol":"PHF8","synonyms":["MRXSSD","JHDM1F","KDM7B"],"name":"PHD finger protein 8","description":"The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]","ncbiEntrezGeneId":23133,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23133","proteins":[{"symbol":"PHF8_HUMAN","href":"/api/1.0/protein/PHF8_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"},{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"}]}