{"symbol":"PHGDH","synonyms":["PDG","NLS1","NLS","SERA","HEL-S-113","PGAD","3-PGDH","PGD","PHGDHD","3PGDH"],"name":"phosphoglycerate dehydrogenase","description":"This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":26227,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26227","proteins":[{"symbol":"SERA_HUMAN","href":"/api/1.0/protein/SERA_HUMAN"}],"hgncRootFamilies":[]}