{"symbol":"PHLPP1","synonyms":["PLEKHE1","SCOP","PHLPP","PPM3A"],"name":"PH domain and leucine rich repeat protein phosphatase 1","description":"This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]","ncbiEntrezGeneId":23239,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23239","proteins":[{"symbol":"PHLP1_HUMAN","href":"/api/1.0/protein/PHLP1_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"},{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}