{"symbol":"PIK3C2G","synonyms":["PI3K-C2-GAMMA","PI3K-C2GAMMA"],"name":"phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma","description":"The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]","ncbiEntrezGeneId":5288,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5288","proteins":[{"symbol":"P3C2G_HUMAN","href":"/api/1.0/protein/P3C2G_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"}]}