{"symbol":"PIK3CD","synonyms":["APDS","P110DELTA","P110D","IMD14"],"name":"phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta","description":"Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]","ncbiEntrezGeneId":5293,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5293","proteins":[{"symbol":"PK3CD_HUMAN","href":"/api/1.0/protein/PK3CD_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"}]}