{"symbol":"PIK3CG","synonyms":["PIK3","PI3CG","PI3KGAMMA","P120-PI3K","P110GAMMA"],"name":"phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma","description":"Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]","ncbiEntrezGeneId":5294,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5294","proteins":[{"symbol":"PK3CG_HUMAN","href":"/api/1.0/protein/PK3CG_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"}]}