{"symbol":"PIK3R1","synonyms":["P85-ALPHA","AGM7","IMD36","GRB1","p85"],"name":"phosphoinositide-3-kinase, regulatory subunit 1 (alpha)","description":"Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]","ncbiEntrezGeneId":5295,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5295","proteins":[{"symbol":"P85A_HUMAN","href":"/api/1.0/protein/P85A_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}