{"symbol":"PIK3R3","synonyms":["P55PIK","P55-GAMMA"],"name":"phosphoinositide-3-kinase, regulatory subunit 3 (gamma)","description":"Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]","ncbiEntrezGeneId":8503,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8503","proteins":[{"symbol":"P55G_HUMAN","href":"/api/1.0/protein/P55G_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}