{"symbol":"PIK3R6","synonyms":["C17ORF38","P84 PIKAP","HST41028","P87(PIKAP)","P87PIKAP"],"name":"phosphoinositide-3-kinase, regulatory subunit 6","description":"Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]","ncbiEntrezGeneId":146850,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/146850","proteins":[{"symbol":"PI3R6_HUMAN","href":"/api/1.0/protein/PI3R6_HUMAN"}],"hgncRootFamilies":[]}