{"symbol":"PILRB","synonyms":["FDFACT1","FDFACT2"],"name":"paired immunoglobin-like type 2 receptor beta","description":"The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]","ncbiEntrezGeneId":29990,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/29990","proteins":[{"symbol":"PILRB_HUMAN","href":"/api/1.0/protein/PILRB_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}