{"symbol":"PIM1","synonyms":["PIM"],"name":"Pim-1 proto-oncogene, serine/threonine kinase","description":"The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":5292,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5292","proteins":[{"symbol":"PIM1_HUMAN","href":"/api/1.0/protein/PIM1_HUMAN"}],"hgncRootFamilies":[]}