{"symbol":"PJA1","synonyms":["RNF70","PRAJA1"],"name":"praja ring finger 1, E3 ubiquitin protein ligase","description":"This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked cognitive disability disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]","ncbiEntrezGeneId":64219,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64219","proteins":[{"symbol":"PJA1_HUMAN","href":"/api/1.0/protein/PJA1_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}