{"symbol":"PKD2","synonyms":["APKD2","PKD4","PC-2","TRPP2"],"name":"polycystic kidney disease 2 (autosomal dominant)","description":"This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]","ncbiEntrezGeneId":5311,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5311","proteins":[{"symbol":"PKD2_HUMAN","href":"/api/1.0/protein/PKD2_HUMAN"}],"hgncRootFamilies":[{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"},{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"}]}