{"symbol":"PLA2G3","synonyms":["SPLA2III","GIII-SPLA2","SPLA2-III"],"name":"phospholipase A2, group III","description":"This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer\u0027s disease. [provided by RefSeq, Apr 2014]","ncbiEntrezGeneId":50487,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/50487","proteins":[{"symbol":"PA2G3_HUMAN","href":"/api/1.0/protein/PA2G3_HUMAN"}],"hgncRootFamilies":[{"name":"Phospholipases","href":"/api/1.0/gene_family/Phospholipases"}]}