{"symbol":"PLB1","synonyms":["HPLB","PLB/LIP"],"name":"phospholipase B1","description":"This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":151056,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/151056","proteins":[{"symbol":"PLB1_HUMAN","href":"/api/1.0/protein/PLB1_HUMAN"}],"hgncRootFamilies":[{"name":"Phospholipases","href":"/api/1.0/gene_family/Phospholipases"}]}