{"symbol":"PLCB1","synonyms":["PLCB1B","PLCB1A","PLC-154","PLC-I","PLC-beta-1","PLC154","EIEE12"],"name":"phospholipase C, beta 1 (phosphoinositide-specific)","description":"The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":23236,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23236","proteins":[{"symbol":"PLCB1_HUMAN","href":"/api/1.0/protein/PLCB1_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"},{"name":"Phospholipases","href":"/api/1.0/gene_family/Phospholipases"}]}