{"symbol":"PLCD3","synonyms":["PLC-DELTA-3"],"name":"phospholipase C, delta 3","description":"This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":113026,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/113026","proteins":[{"symbol":"PLCD3_HUMAN","href":"/api/1.0/protein/PLCD3_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"},{"name":"Phospholipases","href":"/api/1.0/gene_family/Phospholipases"}]}