{"symbol":"PLD3","synonyms":["HUK4","HU-K4","SCA46","AD19"],"name":"phospholipase D family, member 3","description":"This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]","ncbiEntrezGeneId":23646,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23646","proteins":[{"symbol":"PLD3_HUMAN","href":"/api/1.0/protein/PLD3_HUMAN"}],"hgncRootFamilies":[{"name":"Phospholipases","href":"/api/1.0/gene_family/Phospholipases"}]}