{"symbol":"PLEK2","synonyms":[],"name":"pleckstrin 2","description":"The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]","ncbiEntrezGeneId":26499,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26499","proteins":[{"symbol":"PLEK2_HUMAN","href":"/api/1.0/protein/PLEK2_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}