{"symbol":"PLP1","synonyms":["GPM6C","PMD","PLP","HLD1","MMPL","PLP/DM20","SPG2"],"name":"proteolipid protein 1","description":"This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]","ncbiEntrezGeneId":5354,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5354","proteins":[{"symbol":"MYPR_HUMAN","href":"/api/1.0/protein/MYPR_HUMAN"}],"hgncRootFamilies":[]}