{"symbol":"PLXNA2","synonyms":["OCT","PLXN2"],"name":"plexin A2","description":"This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5362,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5362","proteins":[{"symbol":"PLXA2_HUMAN","href":"/api/1.0/protein/PLXA2_HUMAN"}],"hgncRootFamilies":[{"name":"Plexins (PLXN)","href":"/api/1.0/gene_family/Plexins+%28PLXN%29"}]}