{"symbol":"PMAIP1","synonyms":["NOXA"],"name":"phorbol-12-myristate-13-acetate-induced protein 1","description":"This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020]","ncbiEntrezGeneId":5366,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5366","proteins":[{"symbol":"APR_HUMAN","href":"/api/1.0/protein/APR_HUMAN"}],"hgncRootFamilies":[]}