{"symbol":"POLD3","synonyms":["P66","PPP1R128"],"name":"polymerase (DNA-directed), delta 3, accessory subunit","description":"This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\u0027 to 5\u0027 exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":10714,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10714","proteins":[{"symbol":"DPOD3_HUMAN","href":"/api/1.0/protein/DPOD3_HUMAN"}],"hgncRootFamilies":[{"name":"Polymerases, DNA-directed (POL)","href":"/api/1.0/gene_family/Polymerases%2C+DNA-directed+%28POL%29"},{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}