{"symbol":"POLR2E","synonyms":["RPB5","XAP4","HSRPB5","HRPB25","RPABC1"],"name":"polymerase (RNA) II (DNA directed) polypeptide E, 25kDa","description":"This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]","ncbiEntrezGeneId":5434,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5434","proteins":[{"symbol":"RPAB1_HUMAN","href":"/api/1.0/protein/RPAB1_HUMAN"}],"hgncRootFamilies":[{"name":"RNA polymerase subunits (POLR)","href":"/api/1.0/gene_family/RNA+polymerase+subunits+%28POLR%29"}]}