{"symbol":"POLR2J2","synonyms":["RPB11b1","HRPB11B","POLR2J3"],"name":"polymerase (RNA) II (DNA directed) polypeptide J2","description":"This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3\u0027 end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":246721,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/246721","proteins":[{"symbol":"RPB1B_HUMAN","href":"/api/1.0/protein/RPB1B_HUMAN"}],"hgncRootFamilies":[{"name":"RNA polymerase subunits (POLR)","href":"/api/1.0/gene_family/RNA+polymerase+subunits+%28POLR%29"}]}