{"symbol":"PON3","synonyms":[],"name":"paraoxonase 3","description":"This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5446,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5446","proteins":[{"symbol":"PON3_HUMAN","href":"/api/1.0/protein/PON3_HUMAN"}],"hgncRootFamilies":[{"name":"Paraoxonases (PON)","href":"/api/1.0/gene_family/Paraoxonases+%28PON%29"}]}