{"symbol":"POU2F3","synonyms":["OCT-11","SKN-1A","EPOC-1","PLA1","OCT11","OTF-11","PLA-1"],"name":"POU class 2 homeobox 3","description":"This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]","ncbiEntrezGeneId":25833,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/25833","proteins":[{"symbol":"PO2F3_HUMAN","href":"/api/1.0/protein/PO2F3_HUMAN"}],"hgncRootFamilies":[{"name":"Homeoboxes","href":"/api/1.0/gene_family/Homeoboxes"}]}