{"symbol":"PPL","synonyms":[],"name":"periplakin","description":"The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5493,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5493","proteins":[{"symbol":"PEPL_HUMAN","href":"/api/1.0/protein/PEPL_HUMAN"}],"hgncRootFamilies":[{"name":"Plakins","href":"/api/1.0/gene_family/Plakins"}]}