{"symbol":"PPM1B","synonyms":["PP2C-BETA-X","PP2C-BETA","PPC2BETAX","PP2CBETA","PP2CB"],"name":"protein phosphatase, Mg2+/Mn2+ dependent, 1B","description":"The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5495,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5495","proteins":[{"symbol":"PPM1B_HUMAN","href":"/api/1.0/protein/PPM1B_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}