{"symbol":"PPP3CA","synonyms":["CALNA1","CNA1","IECEE1","CALNA","CALN","PPP2B","IECEE"],"name":"protein phosphatase 3, catalytic subunit, alpha isozyme","description":"Enables several functions, including ATPase binding activity; calmodulin binding activity; and calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; negative regulation of angiotensin-activated signaling pathway; and peptidyl-serine dephosphorylation. Located in cytoplasm; cytoplasmic side of plasma membrane; and dendritic spine. Part of calcineurin complex. Implicated in developmental and epileptic encephalopathy 91. Biomarker of cholangiocarcinoma; focal segmental glomerulosclerosis; and schizophrenia. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":5530,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5530","proteins":[{"symbol":"PP2BA_HUMAN","href":"/api/1.0/protein/PP2BA_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}