{"symbol":"PPP3CB","synonyms":["CALNA2","PP2BBETA","CALNB","CNA2"],"name":"protein phosphatase 3, catalytic subunit, beta isozyme","description":"Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in several processes, including calcineurin-NFAT signaling cascade; positive regulation of lysosome organization; and positive regulation of protein localization to nucleus. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":5532,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5532","proteins":[{"symbol":"PP2BB_HUMAN","href":"/api/1.0/protein/PP2BB_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}