{"symbol":"PRAME","synonyms":["OIP-4","CT130","MAPE","OIP4"],"name":"preferentially expressed antigen in melanoma","description":"This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]","ncbiEntrezGeneId":23532,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23532","proteins":[{"symbol":"PRAME_HUMAN","href":"/api/1.0/protein/PRAME_HUMAN"}],"hgncRootFamilies":[{"name":"PRAME family (PRAMEF)","href":"/api/1.0/gene_family/PRAME+family+%28PRAMEF%29"}]}